When the hypothalmus decides we need more thyroid hormone in circulation (cold weather or increased activity level for example) it sends a chemical messenger called thyrotropin-releasing hormone (TRH) which goes to the pituitary gland. The pituitary than sends thyroid stimulating hormone (TSH) over to the thyroid. TSH activates the production of a protein called thyroglobulin.
It has been hypothesized that these compounds activate a complex defense system that maintains normal thyroid function by protecting the gland from both hydrogen peroxide (H2O2), produced by thyrocytes and oxidative stress. This is the major cofactor for the key thyroid enzyme 5’deiodinase which is what converts T4 into T3. 5’deoidinase also degrades the inactive rT3.
"Secondary" or "tertiary" hypothyroidism occurs when the decrease in thyroid hormone is due to a defect of the pituitary gland or hypothalamus. A special test, known as the TRH test, can help distinguish if the disease is caused by a defect in the pituitary or the hypothalamus. This test requires an injection of the TRH hormone and is performed by a doctor that treats thyroid conditions (endocrinologist or hormone specialist).
Also available on the market are combination medications that contain both synthetic T4 and T3 hormones, but such medications aren’t usually recommended. For one thing, most patients see their condition improve with synthetic T4 alone because of the ability of the thyroid to convert these hormones to T3 when needed. Also, synthetic T3-T4 combination drugs can cause anxiety — if you have a preexisting mental health disability, such side effects may be even greater. (3)
Correcting these problems requires an integrative approach. It involves more than simply taking a thyroid pill. As you’ll see, it involves nutritional support, exercise, stress reduction, supplements, reducing inflammation, and sometimes eliminating certain foods and detoxification from heavy metals (such as mercury and lead) and petrochemical toxins (such as pesticides and PCBs).
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Goitrogen Foods – Eating large amounts of raw Brassica vegetables like broccoli, cauliflower, cabbage, kale, soy and Brussels sprouts might impact thyroid function because these contain goitrogens, molecules that impair thyroid perioxidase. When consuming these cruciferous vegetables, it’s best to steam them for 30 minutes before consuming to reduce the goitrogenic effect and keep portions moderate in size. These pose more of a risk for people with iodine deficiencies.
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Goitrogen Foods — People with hypothyroidism may want to stay away from eating large amounts of raw Brassica vegetables like broccoli, cauliflower, cabbage, kale, soy and Brussels sprouts. These vegetables might impact thyroid function because they contain goitrogens, molecules which impair thyroid perioxidase. (11) When consuming these cruciferous vegetables, it’s best to steam them for 30 minutes before consuming and keep portions moderate in size. These pose more of a risk for people with iodine deficiencies.
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Medication is the first option as treatment for hypothyroidism. Doctors may prescribe different medications to bring the production of thyroid hormone to normal levels. However thyroid medications tend to react differently to different people and it may take a while to find the drug that best suits your individual case. In the meantime, you can also try some natural remedies for hypothyroidism. Always make it a point to keep your doctor in the loop however, as most natural treatments have not been subjected to rigorous testing and some could in fact have an adverse effect or interfere with the action of medications. The use of exercise and supplements is thought to help in the natural treatment of hypothyroidism. Including an hour of exercise at least thrice a week is important for the treatment of hypothyroidism. In addition to this, you can speak to your doctor about what supplements you should be having along with the proper dosages.
Alcohol consumption can wreak havoc on both thyroid hormone levels in the body and the ability of the thyroid to produce hormone. Alcohol appears to have a toxic effect on the thyroid gland and suppresses the ability of the body to use thyroid hormone. Ideally, people with hypothyroidism should cut out alcohol completely or drink in careful moderation.
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Please Note: The material on this site is provided for informational purposes only and is not medical advice. Always consult your physician before beginning any diet or exercise program.
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